Getting Started
Initiate a Project

To start screening, please fill out the screen proposal form and email to htcbmgr@sfu.ca.

  • The screen proposal form will summarizes your aims, as well as your protocol. See our Additional Resources section for some useful information on screening development.

  • After your request has been submitted, you will be contacted to set up an initial meeting.

Complete User Agreements 

After your project has been accepted, complete the following forms and and email to htcbmgr@sfu.ca.

  1. User registration form
  2. User agreement form (select the form most applicable)
Obtain Biosafety Review/Approval

All users must obtain biosafety review (external user) or biosafety approval (internal users).

 
Register at BookitLabs

Register at the BookitLabs website, which handles all instrument reservations. More information about equipment c

  1. FIPPA ​consent form (consent is required to use BookitLab)
  2. BookitLab registration

Training

All users must receive training sessions on the pieces of equipment that will be using. You will be prompted to arrange a training session with the HTCB Research Scientist upon your first time booking each piece of equipment.

Screening Pipeline

For more information about the screening pipeline, please consult our pipeline flowchart.

 
Additional Resources

Information for screening development

To assist in the development of screens and to aid in identifying promising chemical matter we have started a small collection of literature references that users and potential users should find useful as a point of reference. The topics covered include:

Note that hits obtained from high throughput screens are a starting point and require rigorous follow up assessment including evaluation of resynthesized compound, validation in a distinct secondary assay, and assessing the quality of the hit to rule out, for example, promiscuous electrophilic compounds or redox active compounds known as PAINS. Also reasonable common are hits that inhibit enzyme activity through compounds aggregating to form microscopic colloids that inhibit or inactivate compounds. 

Media 

Pictures, videos, and PowerPoint template available for download and use.

 
Centre for High-ThroughPut Screening
Simon Fraser University
TASC2 8201, 8888 University Drive, Burnaby, BC V5A 1S6, Canada   |  Contact Us